colitis model

By Targets:	Antibiotic (1) Apoptosis (2) Autophagy (1) Bacterial (1) Deubiquitinase (1) Drug Metabolite (1) Fluorescent Dye (1) Fungal (1) Guanylate Cyclase (2) HIF/HIF Prolyl-Hydroxylase (1) Interleukin Related (4) JAK (2) mAChR (1) mTOR (1) NF-κB (1) NOD-like Receptor (NLR) (3) Phosphodiesterase (PDE) (1) Proteasome (1) Pyroptosis (1) Salt-inducible Kinase (SIK) (1) TNF Receptor (2) Toll-like Receptor (TLR) (1)
By Research Areas:	Cancer (5) Infection (1) Inflammation/Immunology (18)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-125850

Berberrubine chloride

Drug Metabolite Inflammation/Immunology

Berberrubine chloride is an active metabolite of berberine, attenuates ulcerative colitis in mice model .

Berberrubine chloride	Drug Metabolite	Inflammation/Immunology
Berberrubine chloride is an active metabolite of berberine, attenuates ulcerative colitis in mice model .

HY-118704

P-2281	mTOR	Inflammation/Immunology Cancer
P-2281 is a mTOR inhibitor with anticancer and anti-inflammatory efficacies. P-2281 suppresses dextran sulfate sodium (DSS)-induced colitis by inhibiting T cell function and is efficacious in a murine model of human colitis .

HY-N0648

Monotropein	Others	Inflammation/Immunology
Monotropein is an iridoid glycoside isolated Morinda officinalis. Monotropein inhibits the expression of inflammatory mediators in dextran sulfate sodium (DSS)-induced colitis mouse model .

HY-162013

NLRP3-IN-26	NOD-like Receptor (NLR) Pyroptosis	Inflammation/Immunology
NLRP3-IN-26 (compound 15Z) is a NLRP3 inhibitor with the IC₅₀ of 0.13 μM. NLRP3-IN-26 can be used for DSS-induced colitis model study .

HY-156025

HCAR2 agonist 1	Others	Inflammation/Immunology
HCAR2 agonist 1 (Compound 9n) is a G_i protein-biased allosteric modulator of HCAR2. HCAR2 agonist 1 activates the G_i protein signaling pathway. HCAR2 agonist 1 shows anti-inflammatory effect, and reduces mRNA level of pro-inflammatory cytokine (TNF-α, IL-1β, IL-6, and MCP-1). HCAR2 agonist 1 enhances anti-inflammatory effects of orthosteric agonists in the mouse model of colitis .

HY-145829

Tofacitinib Prodrug-1	JAK Apoptosis	Inflammation/Immunology
Tofacitinib precursor-1 is an effective and oral active precursor to mitigate the systemic adverse effects of Tofacitinib. Tofacitinib precursor-1 can effectively attenuate the oxazolone-induced colitis in mice model with low toxicity. Tofacitinib precursor-1 is a potential drug candidate for the research of ulcerative colitis .

HY-114360A

Taurohyodeoxycholic acid sodium 1 Publications Verification	Interleukin Related TNF Receptor	Inflammation/Immunology
Taurohyodeoxycholic acid (THDCA) sodium is the taurine-conjugated form of the secondary bile acid hyodeoxycholic acid. Taurohyodeoxycholic acid can also reduce the activity and expression of myeloperoxidase TNF-α and IL-6, as well as colonic damage in TNBS-induced ulcerative colitis mouse model.

HY-P99439

Anrukinzumab IMA-638	Interleukin Related	Inflammation/Immunology
Anrukinzumab (IMA-638) is a humanized anti-IL-13 monoclonal antibody. Anrukinzumab effectively reduces lung inflammation in a cynomolgus monkey model. Anrukinzumab can be used in studies of ulcerative colitis (UC) as well as asthma .

HY-126360

Oxazolone	TNF Receptor Interleukin Related	Inflammation/Immunology
Oxazolone is a haptenizing agent that induces acute or chronic inflammation of the large intestine and is used to construct models of colitis. Oxazolone can cause Th1/Th2-dependent colitis with weight loss and diarrhea. Oxazolone-induced inflammation can be mitigated by neutralizing anti-IL-4 or anti-TNF-α antibodies or decoy IL-13R2-α-FC proteins .

HY-108741

Plecanatide	Guanylate Cyclase	Inflammation/Immunology
Plecanatide, an analogue of Uroguanylin, is an orally active guanylate cyclase-C (GC-C) receptor agonist. Plecanatide activates GC-C receptors to stimulate cGMP synthesis with an EC₅₀ of 190 nM in T84 cells assay. Plecanatide shows anti-inflammatory activity in models of murine colitis .

HY-B1119

Triclosan 5 Publications Verification	Bacterial Fungal Antibiotic Apoptosis	Infection Cancer
Triclosan is a broad-spectrum antibacterial agent that inhibits bacterial fatty acid synthesis at the enoyl-acyl carrier protein reductase (FabI) step. Triclosan inhibits E. coli enoyl-acyl carrier protein reductase (FabI) and FabI containing a glycine-to-valine substitution at position 93 (FabIG93V) with IC₅₀s of 2 µM and 10 µM, respectively. Triclosan causes apoptotic effect in cultured rat neural stem cells (NSC). Triclosan exacerbates colitis and colitis-associated colorectal tumorigenesis in animal models .

HY-156121

NLRP3-IN-20	NOD-like Receptor (NLR)	Inflammation/Immunology Cancer
NLRP3-IN-20 (compound 11) is an orally available inhibitor of the NLRP3 inflammasome with an IC₅₀ of 25 nM for IL-1β secretion. NLRP3-IN-20 has excellent pharmacokinetic properties and demonstrated significant efficacy in models of non-alcoholic steatohepatitis, fatal septic shock, and colitis .

HY-108741A

Plecanatide acetate	Guanylate Cyclase	Inflammation/Immunology
Plecanatide acetate, an analogue of Uroguanylin, is an orally active guanylate cyclase-C (GC-C) receptor agonist. Plecanatide acetate activates GC-C receptors to stimulate cGMP synthesis with an EC₅₀ of 190 nM in T84 cells assay. Plecanatide acetate can be used for the research of chronic idiopathic constipation, and it also shows anti-inflammatory activity in models of murine colitis .

HY-117370

USP25/28 inhibitor AZ1 1 Publications Verification AZ1	Deubiquitinase	Cancer
USP25/28 inhibitor AZ1 (AZ1) is an orally active, selective, noncompetitive, dual ubiquitin specific protease (USP) 25/28 inhibitor with IC₅₀s of 0.7 μM and 0.6 μM, respectively. USP25/28 inhibitor AZ1 attenuates colitis and tumorigenesis in the mice model .

HY-107648

McN-A-343 1 Publications Verification	mAChR	Inflammation/Immunology
McN-A-343 is a selective M1 muscarinic agonist that stimulates muscarinic transmission in sympathetic ganglia. McN-A-343 reduces inflammation and oxidative stress in an experimental model of ulcerative colitis . McN-A-343 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-151252

NIC-0102	Proteasome NOD-like Receptor (NLR)	Inflammation/Immunology
NIC-0102 is an orally active proteasome inhibitor (pIC₅₀=7.55) that specifically inhibits NLRP3 inflammatory vesicle activation. NIC-0102 shows potent anti-inflammatory effects in a model of dextran sulfate sodium (DSS)-induced ulcerative colitis. NIC-0102 also inhibits production of pro-IL-1β .

HY-126242S

Tyk2-IN-7	JAK	Inflammation/Immunology
Tyk2-IN-7 is a TYK2 JH2 inhibitor, binds to TYK2 JH2 domain with IC50 and Ki.app of 0.00053 μM and 0.00007 μM, respectively. Tyk2-IN-7 provides a highly selective alternative to conventional TYK2 orthosteric inhibitors, inhibits TYK2/JAK1/JAK2 kinase domain. Tyk2-IN-7 provides robust inhibition in a mouse IL-12-induced IFNγ pharmacodynamic model as well as efficacy in an IL-23 and IL-12-dependent mouse colitis model[1].

HY-D1377

Citrulline-specific probe-rhodamine hydrate	Fluorescent Dye	Others
Citrulline-specific probe-rhodamine hydrate is a specific probe for citrulline (Citrulline) combined with a rhodamine fluorescent group. Citrulline is the hydrolysis product of arginine catalyzed by protein arginine deiminase (PAD). PAD is abnormally activated in many diseases, leading to increased citrulline levels. Citrulline-specific probe-rhodamine hydrate is a biological probe that can identify diseases showing abnormal increases in PAD activity and may be effectively used in animal models of ulcerative colitis .

HY-15893

DMOG Maximum Cited Publications 47 Publications Verification Dimethyloxallyl Glycine	HIF/HIF Prolyl-Hydroxylase Autophagy	Cancer
DMOG (Dimethyloxallyl Glycine) is a cell permeable and competitive inhibitor of HIF-PH, which results in HIF-1α stabilisation and accmulation in vitro and in vivo . DMOG is an α-ketoglutarate analogue and inhibits α-KG-dependent hydroxylases. DMOG acts as a pro-angiogenic agent and plays a protective role in experimental model of colitis and diarrhoea via HIF-1 related signal . DMOG induces cell autophagy .

HY-149365

SIKs-IN-1	Salt-inducible Kinase (SIK)	Inflammation/Immunology
SIKs-IN-1 (compound 8h), a pyrimidine-5-carboxamide derivative, is a Salt-inducible kinases (SIKs) inhibitor. SIKs regulates the transformation of M1/M2 macrophages, involving in inflammation process. SIKs-IN-1 inhibits SIK activity, up-regulates anti-inflammatory cytokine IL-10, but down-regulates pro-inflammatory cytokine IL-12. SIKs-IN-1 shows excellent anti-inflammatory effects in a DSS-induced colitis model .

HY-N11768

4-Methoxylonchocarpin	NF-κB Interleukin Related Toll-like Receptor (TLR)	Inflammation/Immunology
4-Methoxylonchocarpin is an orally active anti-inflammatory agent. 4-methoxylonchocarpin inhibits the binding of LPS to Toll-like Receptor (TLR) TLR4 to inhibit NF-κB activation and TNF Receptor and IL-6 expression. 4-Methoxylonchocarpin also inhibits the phosphorylation of TGF-beta activated kinase 1 and TNBS-induced expression of IL-1β, IL-17A, and TNF. 4-methoxylonchocarpin can improve 2,4, 6-trinitrobenzene sulfonic acid (TNBS)-induced colitis mouse model .

HY-155199

PDE1-IN-5	Phosphodiesterase (PDE)	Inflammation/Immunology
PDE1-IN-5 (Compound 10c) is a selective PDE1C inhibitor (IC₅₀: 15 nM). PDE1-IN-5 has anti- inflammatory activity, and inhibits expression of iNOS, TNF-α, IL-1α, IL-1β, and IL-6 induced by LPS. PDE1-IN-5 has anti-inflammatory bowel disease (IBD) effects in the dextran sodium sulfate (DSS)-Induced colitis mice model. PDE1-IN-5 can be used for research of IBD .

Cat. No.	Product Name	Type

HY-D1377

Citrulline-specific probe-rhodamine hydrate	Fluorescent Dyes/Probes
Citrulline-specific probe-rhodamine hydrate is a specific probe for citrulline (Citrulline) combined with a rhodamine fluorescent group. Citrulline is the hydrolysis product of arginine catalyzed by protein arginine deiminase (PAD). PAD is abnormally activated in many diseases, leading to increased citrulline levels. Citrulline-specific probe-rhodamine hydrate is a biological probe that can identify diseases showing abnormal increases in PAD activity and may be effectively used in animal models of ulcerative colitis .

Citrulline-specific probe-rhodamine hydrate

Fluorescent Dyes/Probes

Citrulline-specific probe-rhodamine hydrate is a specific probe for citrulline (Citrulline) combined with a rhodamine fluorescent group. Citrulline is the hydrolysis product of arginine catalyzed by protein arginine deiminase (PAD). PAD is abnormally activated in many diseases, leading to increased citrulline levels. Citrulline-specific probe-rhodamine hydrate is a biological probe that can identify diseases showing abnormal increases in PAD activity and may be effectively used in animal models of ulcerative colitis .

Cat. No.	Product Name	Type

HY-114360A

Taurohyodeoxycholic acid sodium 1 Publications Verification	Biochemical Assay Reagents
Taurohyodeoxycholic acid (THDCA) sodium is the taurine-conjugated form of the secondary bile acid hyodeoxycholic acid. Taurohyodeoxycholic acid can also reduce the activity and expression of myeloperoxidase TNF-α and IL-6, as well as colonic damage in TNBS-induced ulcerative colitis mouse model.

Cat. No.	Product Name	Target	Research Area

HY-108741

Plecanatide	Guanylate Cyclase	Inflammation/Immunology
Plecanatide, an analogue of Uroguanylin, is an orally active guanylate cyclase-C (GC-C) receptor agonist. Plecanatide activates GC-C receptors to stimulate cGMP synthesis with an EC₅₀ of 190 nM in T84 cells assay. Plecanatide shows anti-inflammatory activity in models of murine colitis .

HY-108741A

Plecanatide acetate	Guanylate Cyclase	Inflammation/Immunology
Plecanatide acetate, an analogue of Uroguanylin, is an orally active guanylate cyclase-C (GC-C) receptor agonist. Plecanatide acetate activates GC-C receptors to stimulate cGMP synthesis with an EC₅₀ of 190 nM in T84 cells assay. Plecanatide acetate can be used for the research of chronic idiopathic constipation, and it also shows anti-inflammatory activity in models of murine colitis .

Cat. No.	Product Name	Target	Research Area

HY-P99439

Anrukinzumab IMA-638	Interleukin Related	Inflammation/Immunology
Anrukinzumab (IMA-638) is a humanized anti-IL-13 monoclonal antibody. Anrukinzumab effectively reduces lung inflammation in a cynomolgus monkey model. Anrukinzumab can be used in studies of ulcerative colitis (UC) as well as asthma .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-125850

Berberrubine chloride	Alkaloids Structural Classification Phellodendron amurense Rupr. Monophenols Classification of Application Fields Source classification Rutaceae Phenols Plants Isoquinoline Alkaloids Inflammation/Immunology Disease Research Fields	Drug Metabolite
Berberrubine chloride is an active metabolite of berberine, attenuates ulcerative colitis in mice model .

HY-N0648

Monotropein	Iridoids Classification of Application Fields Terpenoids Pyrola calliantha H. Andr. Source classification Pyrolaceae Rubiaceae Plants Morinda officinalis How Inflammation/Immunology Disease Research Fields	Others
Monotropein is an iridoid glycoside isolated Morinda officinalis. Monotropein inhibits the expression of inflammatory mediators in dextran sulfate sodium (DSS)-induced colitis mouse model .

HY-N11768

4-Methoxylonchocarpin	Structural Classification Monophenols Source classification Phenols Plants Moraceae Dorstenia mannii Hook.f.	NF-κB Interleukin Related Toll-like Receptor (TLR)
4-Methoxylonchocarpin is an orally active anti-inflammatory agent. 4-methoxylonchocarpin inhibits the binding of LPS to Toll-like Receptor (TLR) TLR4 to inhibit NF-κB activation and TNF Receptor and IL-6 expression. 4-Methoxylonchocarpin also inhibits the phosphorylation of TGF-beta activated kinase 1 and TNBS-induced expression of IL-1β, IL-17A, and TNF. 4-methoxylonchocarpin can improve 2,4, 6-trinitrobenzene sulfonic acid (TNBS)-induced colitis mouse model .

Cat. No.	Product Name	Chemical Structure

HY-126242S

Tyk2-IN-7
Tyk2-IN-7 is a TYK2 JH2 inhibitor, binds to TYK2 JH2 domain with IC50 and Ki.app of 0.00053 μM and 0.00007 μM, respectively. Tyk2-IN-7 provides a highly selective alternative to conventional TYK2 orthosteric inhibitors, inhibits TYK2/JAK1/JAK2 kinase domain. Tyk2-IN-7 provides robust inhibition in a mouse IL-12-induced IFNγ pharmacodynamic model as well as efficacy in an IL-23 and IL-12-dependent mouse colitis model[1].

Tyk2-IN-7

Tyk2-IN-7 is a TYK2 JH2 inhibitor, binds to TYK2 JH2 domain with IC50 and Ki.app of 0.00053 μM and 0.00007 μM, respectively. Tyk2-IN-7 provides a highly selective alternative to conventional TYK2 orthosteric inhibitors, inhibits TYK2/JAK1/JAK2 kinase domain. Tyk2-IN-7 provides robust inhibition in a mouse IL-12-induced IFNγ pharmacodynamic model as well as efficacy in an IL-23 and IL-12-dependent mouse colitis model[1].

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